FMRFamide is a neuropeptide identified in Hard clam Mercenaria mercenaria thought to play an important role in cardiac activity regulation. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region (Higgins et al, 1978).
Its precursor (FMFRamide-related protein) plays role in heart rate (HR) and blood pressure and in reduction of morphine-induced antinociception.
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