ISS generally refers to the International Space Station, but may also refer to:
- Injury Severity Score, an established medical score used to asses the severity of trauma
- ISS A/S, a Danish service company
- Institute for Security Studies regional think tank in Africa
- Institute for Security Studies (EU) a European Union think tank
- Institute of Strategic Studies regional think tank in Pakistan
- Institute of Social Studies, international institute of higher education on social and economic change with a focus on development processes
- Industrial Sounding System, proposed method of launching inert objects into low orbit with the use of a cannon
- International Superstar Soccer, series of Japanese soccer video games by Konami
- Internet Security Systems, security software vendor
- Imaging Science Subsystem, a set of cameras aboard the Cassini spacecraft
- International Seismological Summary, global earthquake catalog for the time period between 1918 and 1963
- Imperial Star Ship, in the Star Trek Mirror Universe is a space ship of the Terran Empire
- International Social Services, a charitable, non-governmental organisation
- International School of Stavanger, a private Primary, Middle and High School in Stavanger, Norway
- International Security Academy Israel - formerly known as ISS - Int. Security School]
- Instruction Set Simulator, computer program that simulates a processor at the instruction-set level
- Indian Springs School, a boarding school in Birmingham, Alabama
- Innisdale Secondary School, a high school in Barrie, Ontario
- In-school suspension, a form of punishment in some schools
- Idiopathic Short Stature, an unexplained short stature.
- Input to state stability, which is a notion in control theory
- Ion scattering spectroscopy, a materials analysis method.
- Idea Star Singer, A Malayalam music reality show by Asianet TV.
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