Importin.html



PDB Molecule of the Month pdb85_1

Importin is a type of protein that moves other protein molecules into the nucleus by binding to a specific recognition sequence, called the nuclear localization signal (NLS). Importin is classified as a karyopherin.¹²

Importin has two subunits, importin α and importin β. Of these, importin α binds to the NLS of the protein to be imported to the nucleus whereas importin β helps in the docking of the importin heterodimer-bound protein to the nuclear pore complex. The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus.³

Genes

• Importin: IPO4, IPO7, IPO8, IPO9, IPO11, IPO13
• Karyopherin-α: KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6
• Karyopherin-β: KPNB1

References

External links

• MeSH Importins

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