Isoguanine.html
 
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Isoguanine
IUPAC name 6-Amino-1,7-dihydropurin-2-one
Other names 2-Hydroxyadenine
Identifiers
CAS number 3373-53-3
PubChem 76900
SMILES
 
Properties
Molecular formula C5H5N5O
Molar mass 151.1261
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references

Isoguanine or 2-hydroxyladenine is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation.1 It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.

References

  1. ^ Yang XL, Sugiyama H, Ikeda S, Saito I, Wang AH (1998). "Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy". Biophys. J. 75 (3): 1163–71. PMID 9726918. 


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