A mutation is a change in the sequence of an organism's genetic material.
Mutation may also refer to:
- Mutation (genetic algorithm), an operator in a genetic algorithm
- Consonant mutation, in linguistics, a change in a consonant sound
- Apophony, in linguistics, a change in a sound in a word
- Mutation (knot theory), an operation on a knot that creates different knots
- Mutation (novel), a medical thriller by Robin Cook
- Mutations (album), an indie rock album by Beck
- Mutations (Fight album), by the metal band Fight
- Mutate (comics), a group and term used in Marvel Comics
- Savage Land Mutates, a group of mutants in Marvel Comics
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