NADPH.html



Nicotinamide adenine dinucleotide phosphate
Identifiers
CAS number	53-59-8
PubChem	929
MeSH	NADP
Properties
Molecular formula	C21H29N7O17P3
Molar mass	744.413
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Nicotinamide adenine dinucleotide phosphate (NADP⁺, in older notation triphosphopyridine nucleotide, TPN) is used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

NADPH is the reduced form of NADP⁺, and NADP⁺ is the oxidized form of NADPH. NADP+ differs from NAD+ by the presence in NADP+ of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety.

In plants

In chloroplasts, NADP is reduced by ferredoxin-NADP+ reductase in last step of the electron chain of the light reactions of photosynthesis. The NADPH produced is then used as reducing power for the biosynthetic reactions in the Calvin cycle of photosynthesis.

In animals

The oxidative phase of the pentose phosphate pathway is the major source of NADPH in cells.

NADPH provides the reducing equivalents for biosynthetic reactions and for oxidation-reduction involved in protection against the toxicity of ROS (reactive oxygen species).

NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis and fatty acid chain elongation.

It is the source of reducing equivalents for cytochrome 450 hydroxylation of aromatic compounds, steroids, alcohols, and drugs.

Ball-and-stick model of NADP+

Ball-and-stick model of NADPH

See also

• Nicotinamide adenine dinucleotide