Shikimate kinase.html



Shikimate kinase of Erwinia chrysanthemi
Identifiers
Symbol	SKI
Pfam	PF01202
InterPro	IPR000623
PROSITE	PDOC00868
SCOP	2shk
OPM protein	1e6c
Available PDB structures: 1l4yA:11-167 1we2A:11-167 1l4uA:11-167 1u8aA:11-167 2shkB:11-169 1shkA:11-169 1e6cB:11-169 1kagA:13-171 2IYQ 2IYR 2IYS 2IYT 2IYU 2IYV 2IYW 2IYX 2IYY 2IYZ

In enzymology, a shikimate kinase (EC 2.7.1.71) is an enzyme that catalyzes the chemical reaction

ATP + shikimate ADP + shikimate 3-phosphate

Thus, the two substrates of this enzyme are ATP and shikimate, whereas its two products are ADP and shikimate 3-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:shikimate 3-phosphotransferase. Other names in common use include shikimate kinase (phosphorylating), and shikimate kinase II. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

Structural studies

As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes 1E6C, 1KAG, 1L4U, 1L4Y, 1SHK, 1U8A, 1VIA, 1WE2, 1ZUH, 1ZUI, 1ZYU, 2DFN, 2DFT, 2G1J, 2G1K, 2IYQ, 2IYR, 2IYS, 2IYT, 2IYU, 2IYV, 2IYW, 2IYX, 2IYY, 2IYZ, and 2SHK.

Human proteins containing this domain

MAPK7; THNSL1;

References

• IUBMB entry for 2.7.1.71
• BRENDA references for 2.7.1.71 (Recommended.)
• PubMed references for 2.7.1.71
• PubMed Central references for 2.7.1.71
• Google Scholar references for 2.7.1.71
• Morell H, Sprinson DB (1968). "Shikimate kinase isoenzymes in Salmonella typhimurium". J. Biol. Chem. 243: 676–7. PMID 4866525. 
• Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD (2006). "Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.". J. Mol. Biol. 364: 411–23. doi:10.1016/j.jmb.2006.09.001. PMID 17020768. 

External links

The CAS registry number for this enzyme class is 9031-51-0.

• IUBMB entry for 2.7.1.71

• KEGG entry for 2.7.1.71

• BRENDA entry for 2.7.1.71

• NiceZyme view of 2.7.1.71

• EC2PDB: PDB structures for 2.7.1.71

• PRIAM entry for 2.7.1.71

• PUMA2 entry for 2.7.1.71

• IntEnz: Integrated Enzyme entry for 2.7.1.71

• MetaCyc entry for 2.7.1.71

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004765: shikimate kinase

• AMIGO entry for GO code 0004765: shikimate kinase

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