Thiamine pyrophosphate.html



Thiamine pyrophosphate
IUPAC name	2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate
Other names	Thiamine diphosphate
Identifiers
CAS number	154-87-0
PubChem	1132
MeSH	Thiamine+pyrophosphate
SMILES	[n+]1(c(c(CCO[P@@](OP(O)(O)=O)(O)=O)sc1)C)Cc1c(nc(C)nc1)N.[ClH-]
Properties
Molecular formula	C12H19N4O7P2S+
Molar mass	425.316
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Thiamine pyrophosphate (TPP) or thiamine diphosphate (ThDP) is a thiamine derivative which is cleaved by thiamine pyrophosphatase. Thiamine pyrophosphate is the active form of thiamine (vitamin B1).¹

ThDP is a prosthetic group in many enzymes, such as:

• Pyruvate dehydrogenase complex
• Pyruvate decarboxylase complex in ethanol fermentation
• Alpha-ketoglutarate dehydrogenase complex
• Branched-chain amino acid dehydrogenase complex
• 2-hydroxyphytanoyl-CoA lyase
• Transketolase

References

1. ^ Glactone: Vitamin B1

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